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Excessive exposure to manganese can worsen the gradual decline in fine motor skills often associated with aging Women tend to have higher levels of manganese

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In young healthy subjects (n = 80, age 25.4 0.2), this effect is achieved with higher doses and is correlated with L-arginine plasma concentrations ( From clinical trials testing the effects of oral administration of L-arginine, a picture has emerged that short-term L-arginine administration (3 months) provides benefits, whereas longer supplementation (6 months) gives mixed results