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Both pathways require P5P

This key issue is absolutely required, but quite challenging, since these two dimensions correspond to traditionaly different epistemic fields

In 77% children, seizure onset was before the age of 7 months

The CYP-35s protein structure is at this point not unavailable, and although the structure of human CYP2A6 (PDB ID: 2FDV) is available, the sequence shares an identity of only 25% sequence with C.elegans CYP-35A1