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This is increasingly important as more trials move into decentralized, at-home settings without clinical supervision, where patients must rely on the device design and labelling to use it correctly

Clinics generally advise against starting treatment for anyone who: Is pregnant Has a personal or family history of thyroid cancer Has a history of multiple endocrine neoplasia (MEN) syndrome BMI and health history serve as a useful starting point for this evaluation, not an absolute cutoff, since metabolism and overall wellness also weigh into a provider's decision

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Nanocarriers limit the drug's ability to move to other parts of the body, hence reducing systemic adverse effects, by delivering the medication directly to the inflammatory areas of the lungs