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Cell 2013;153:11201133

A1AT has been shown to reduce in vitro apoptosis of neutrophils, by inhibiting the proteasomal degradation of the antiapoptotic protein Mcl-1 (48)

Ultrastructural analysis revealed that cisplatin-treated cells exhibited membrane blebbing without overt rupture (Figures 3I,J), a phenotype that was reversed by LicoA co-administration

Grade of recommendation: C-D In neonates and children with symptomatic hyperammonemia, dialysis should be carried out when ammonia exceeds 500 mol/L or when there is no response within four hours after starting medical treatment