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Conclusions Multiple intracellular and extracellular mechanisms are the root of drug resistance and relapse in AML stem cells, and influence the dormancy, resistance to apoptosis and senescence, epigenetic modification, metabolic reprogramming, and protection of the BM microenvironment

Nano Today (2022) 42:101351

doi: 10.1002/jcsm.70090

380 Activated ERK1/2 switches LSECs to a pro-regenerative phenotype by releasing HGF and Wnt, whereas activated AKT triggers the profibrotic phenotype of LSECs