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Li et al., Mixed-charge self-assembled monolayers as a facile method to design pH-induced aggregation of large gold nanoparticles for near-infrared photothermal cancer therapy

42 Research on mesoporous silica dates back to the 1960s, when some United States patents mentioned the preparation of mesoporous silica, 43,44 but it was not until the 1990s that the study of mesoporous silica received increasing attention from researchers

The release of hemoglobin and iron from red blood cells activates macrophages, leading to the production of inflammatory factors including interleukin-1, interleukin-6, and tumor necrosis factor-alpha (22) and fostering the formation of damaging reactive oxygen species (23)

At the same time, this therapy regulates protective signaling pathways to decrease cell death