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The authors reveal that Ca2+-dependent ER luminal reduction is sensitive to GSH synthesis inhibition or cytosolic GSH dilution, indicating a glutathione-centered mechanism

A total of seven biomarkers of protein nonenzymatic modifications indicating oxidative stress were detected, as described previously [43]

27 However, in humans, the EGFR inhibitor erlotinib largely failed to inhibit tumour growth in a Phase 2 trial of patients with advanced stage MPNST 28 (NCT00068367)