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Toxicity of Glutathione Binding Metals: A Review of Targets and Mechanisms Catabolism of extracellular glutathione supplies cysteine to support tumours Nature Catalytic Glutathione Oxidation and Platinum(IV) Prodrug Activation via a Ruthenium Flavin Catalyst Organometallics Glutaredoxin catalysis requires two distinct glutathione interaction sites Nature Communications

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Importantly, these potential off-target effects do not negate our overall conclusion regarding the pivotal involvement of LRP6 in the pathological process

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