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Replacing calcium with another divalent cation had not been considered in previous in vitro activity measurements

Finally, we showed that dehydroascorbate labeled for positron emission tomography, namely [1- 11 C]dehydroascorbate, showed no change in brain signal accumulation after diethyl maleate treatment

The initial encounter will be electrostatic in origin and obviously important to targeting the proteins to DNA where additional specific interactions may take place