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2 February 2015

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

This enhances the transcription of p53 target genes like p21 ( FIGURE 3 Oxidative Stress-Induced Cell Cycle Deregulation Cyclin-D, which plays a crucial role in initiating the cell cycle in association with Cdk4 or Cdk6 is sensitive to various extracellular stimuli including oxidative stress which modifies its activity through post-transcriptional and post-translational modulations (Stacey, 2010)