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RBC cell membrane defect: Abnormality in the cell membrane cytoskeleton leads to spherocytosis and elliptocytosis

The rapid accumulation of multiple isotopologues in metabolites of upper glycolysis and the pentose phosphate pathway (PPP) revealed that GAPDH inhibition by hydrogen peroxide induces rapid diversion of glycolytic flux into the PPP, and further, multiple rounds of cycling of carbons through the oxidative arm to amplify NADPH production and combat ROS (Fig

Utilizing an unsupervised ML approach by k-means clustering on biomarkers, without histological endpoints or treatment, subjects were categorized into 3 distinct groups: high (Group 1), moderate (Group 2) and low (Group 3) responders

When macrophages internalize oxLDL, they form lipid-laden foam cells within the intima, a distinctive hallmark of early-stage atherosclerotic lesions