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In particular, the group of 119 PD patients, named genetic-PD, includes PD-affected subjects carrying of at least 1 pathogenic mutation in one of the most frequently mutated PD genes which include GBA1 , LRRK2 , PARK2 , PARK7 , PINK1 , and TMEM175

doi: 10.1016/j.ccr.2013.05.003 5 GoldmanAMajumderBDhawanARaviSGoldmanDKohandelMet al

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Hypothyroidism may result in the following symptoms : Weight gain Muscle soreness, weakness Headaches High cholesterol Constipation Fatigue Brittle hair and nails Dry or scaly skin Impaired cognition Enlarged thyroid (goiter) Cold sensitivity Depression Irregular menstruation Low libido Seeking Treatment Hypothyroidism is a complex condition with multiple possible root causes and a host of symptoms that do not occur in every patient