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Peer review Peer review information Nature Communications thanks Ching-Ping Tseng and the other anonymous reviewer(s) for their contribution to the peer review of this work

Combined analysis of transcriptome and metabolome was used to explore potential genes related to glutathione metabolic process (Fig

Drastic changes in the abundance of specific proteins are also responsible for a variety of diseases

The increase in antioxidant defense was supported by the reduced ROS levels observed in 1919 GBM PSPH amp and 1919 GBM PSPH V116I cells compared to parental cells (Fig