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The first marketed date for HCPCS Y0000 would remain January 15, 2022, as noted, given that HCPCS Y0000 includes NDC2, marketed under NDA 000000, for which the earliest date of first sale for any NDC marketed thereunder is NDC1's date of first sale (January 15, 2022)

Peripheral factorsincluding ATPase family AAA domain-containing protein 3 (ATAD3), prohibitin 1/2 (PHB1/2), and mitofusin 1 (MFN1)modulate mitochondrial biogenesis, apoptosis, and mito-nuclear signaling without directly binding to mtDNA [29]

polymeric nanoparticles have been utilized to co-deliver multiple drugs (eg, budesonide and theophylline), resulting in improved therapeutic outcomes in asthma models [41, 38]