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Discussion The present study confirms that the AA homozygous genotype of GSTP1 gene is significantly associated with the risk of oral cancer even after adjusting for age, gender and habit of RAN/tobacco usage in the population

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

CFTRs are folded by HSP70 family proteins, 422 which often recruit other chaperones (i.e., HSP90)

Jalkanen, J