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2023, PMID: 37952131) demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in people with overweight or obesity without diabetes establishing a cardiovascular benefit independent of its weight loss effects

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A comprehensive review of 36 studies (1993-2024) confirms effects on growth factor upregulation, VEGF/VEGFR2 expression, and FAK-paxillin cell migration pathways