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Notably, Hif1a stabilization can also be mediated by changes in proteolytic activity of the proteasome, which is regulated by post-translational modifications in response to ROS [69, 104]

Instead, these domains appeared as blurred density in 2D and as an elongated asymmetric density between the two stalk domains in 3D, suggesting that the pHAT domains adopt a range of different angular positions relative to the catalytic core