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365 As known, leukocytes are promptly recruited when neuroinflammation occurs in brain disorders

Free Radic Biol Med 190:234246 Mancardi D, Mezzanotte M, Arrigo E, Barinotti A, Roetto A (2021) Iron overload, oxidative stress, and ferroptosis in the failing heart and liver

While extended delivery may partly help, it can harm commensal microbiota and worsen inflammation 167,168

Molecules 23(10):2599 Park KS (2013) Aucubin, a naturally occurring iridoid glycoside inhibits TNF--induced inflammatory responses through suppression of NF-B activation in 3T3-L1 adipocytes