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Such damage activates intracellular stress responses that disrupt cell cycle regulation, contributing to genomic instability and carcinogenesis (Tchounwou et al., 2004

This discovery propelled the exploration of the critical role played by glutamine in the functioning and activation of immune cells

In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects

Further, targeted metabolomics and isotope tracing experiments uncovered GGCT as a metabolic orchestrator to prioritize Gln to GSH flux for antioxidant defense, while activating glucose (Glc)-fueled anaplerosis to replenish TCA intermediates to fuel proliferation