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In addition, the immune component of the barrier limits access of environmental antigens, while the biological component is maintained through colonization by commensal microbiota 70

Apart from TAT1, all typical KATs mainly localize to the nucleus and are capable of acetylating both histones and non-histone proteins

In CKD, reduced renal excretion leads to vanadate accumulation, which accelerates eryptosis through multiple metabolic disruptions (Vervloet et al., 2017)

In the light of these findings, the functional plasticity of the intestinal epithelium and its regenerative response to injury are modulated or even controlled by mitochondrial metabolism, supporting the hypothesis that mitochondrial exhaustion contributes to the functional perturbation of the epithelium in IBD (referred to as metabolic injury)