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It has been reported (118121) that ARS can inhibit the proliferation of chondrocytes and accelerate apoptosis and autophagy in RA rats, inhibit the migration and invasion of RA-FLSs and reduce the secretion of IL-1, IL-6 and IL-8, alleviate inflammatory symptoms and prevent the destruction of cartilage and bone, which is related to the inhibition of NF-kB signaling pathway, the activation of PI3K/AKT/mTOR signaling pathway, and the phosphorylation of p90 ribosomal kinase 2 (RSK2)

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FIGURE 6 4.4.1 Dynamic equilibrium and drug resistance of m 6 A modification m 6 A modification dynamically regulates RNA metabolism through the writer-eraser-reader ternary system: METTL3/WTAP complex recognizes the GGACU motif of RRM2 mRNA, adds an m 6 A mark to its 3UTR, recruits YTHDF2 reader, enhances mRNA stability and promotes translation (Zaccara et al., 2019)

The prevalence of IC/BPS is higher in women (45300/100,000) than in men (830/100,000)