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Without intrinsic factor, oral supplements won't work, making injectable B12 for humans often necessary

10.7759/cureus.36058 145

These results suggest that radiation-induced disruption of the gut flora increases levels of pro-inflammatory cytokines (Gerassy-Vainberg et al., 2018)

However, due to its synthetic nature it is also the least bioavailable and active (Hunt, Harrington and Robinson, 2014) Methylcobalamin: The first of our non-synthetic forms of B12 is methylcobalamin, a naturally occurring co-enzyme