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As a biomarker in clinical practice, it has been suggested as a proxy to evaluate neuroinflammation ( Although CNS IDDs might differ in several aspects, as previously mentioned, the extensive role performed by glial cells in neuroinflammation is a convergence point among them

CIT, classified as a non-essential amino acid and a precursor to L-arginine, has been shown to facilitate the production of NO and promote vasodilation, consequently enhancing endothelial functionality and muscle perfusion (911)

Narcan removes opioids from receptors in the central nervous system and replaces the opioids without activating the receptor

The antioxidant effects of vitamin C and curcumin have been investigated in suppressing PIPN with demonstrated benefits in the reduction of TNF and IL6 levels in the DRG of rats [23, 24]