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When Wnt pathway activation occurs, Twa1 translocates to the nucleus, and its conserved CRA (CT11-RanBPM) domain is required for its interaction with -catenin, which promotes -catenin nuclear retention and increases Wnt/-catenin downstream target gene expression

Glossary m Mitochondrial membrane potential 25(OH)D 25-Hydroxyvitamin D 3-HSD 3-beta-Hydroxysteroid dehydrogenase 4-HNE 4-hydroxynonenal 8-OHdG 8-hydroxy-2-deoxyguanosine ADMA Asymmetric dimethylarginine AGE Advanced glycation end products AMH Anti-Mllerian hormone AMPK Adenosine monophosphate-activated protein kinase ART Assisted reproductive technology CAT Catalase CoA Coenzyme A Cyp Cytochrome DCI D-chiro-inositol DHEA Dehydroepiandrosterone DHT Dihydrotestosterone ELISA Enzyme-linked immunosorbent assay ETC Electron transport chain FSH Follicle-stimulating hormone GF Graafian follicle GH Growth Hormone GLUT-4 Glucose transporter type 4 GPx Glutathione peroxidase GR Glutathione reductase GRAS Generally recognized as safe GSH Glutathione GSH/GSSG Reduced-to-oxidized glutathione HA Hyperandrogenism HbA1c Glycated hemoglobin HDL High-density lipoprotein HPG Hypothalamicpituitary-gonadal HPO Hypothalamic-pituitary-ovarian hs-CRP High-sensitivity C-reactive protein ICSI Intracytoplasmic sperm injection IL-10 Interleukin-10 IL-17 Interleukin-17 IL-6 Interleukin-6 IPG Inositolphosphoglycan IR Insulin resistance IRS Insulin receptor substrate IVF In vitro fertilization LDL Low-density lipoprotein LH Luteinizing hormone LPO Lipid peroxidation MAPK Mitogen-activated protein kinase MDA Malondialdehyde MI Myo-inositol MII Metaphase II MP Multilaminar primary follicle mtDNA Mitochondrial DNA NADPH Nicotinamide adenine dinucleotide phosphate NF-B Nuclear factor-kappa B NMRI Naval Medical Research Institute NO Nitric oxide NOS Nitric oxide synthase NOX NADPH oxidase NRF Nuclear related factor OCP Oral Contraceptive Pill OS Oxidative stress P Primordial follicle PCOS Polycystic ovary syndrome PI3K Phosphatidylinositol 3-kinase PPAR Peroxisome proliferator-activated receptor gamma p-STAT3 Phosphorylated signal transducer and activator of transcription 3 PUFA Polyunsaturated fatty acid RAS Renin angiotensin system ROS Reactive oxygen species RXR Retinoid X receptor SCFA Short-chain fatty acid SCN Suprachiasmatic nucleus SF Secondary follicle SHBG Sex hormone-binding globulin SOD Superoxide dismutase StAR Steroidogenic acute regulatory TAC Total antioxidant capacity TNF Tumor necrosis factor alpha TSH Thyroid-stimulating hormone UP Uilaminar primary follicle FDA United States Food and Drug Administration VDR Vitamin D receptor VDRE Vitamin D response elements VLDL Very low-density lipoprotein WHO World Health Organization References 1 SuPChenCSunY

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Ancient Greek, Persian, and Roman physicians documented using snow, ice, and cold water for treating injuries and diseases