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For instance, in human coronary artery endothelial cells, selective inhibition of PKC- by RBX during simulated ischemiareperfusion significantly restored Akt activation, enhanced anti-apoptotic signaling (iNOS, p-BAD), and suppressed pro-apoptotic mediators (p-FOXO, cleaved PARP, and caspase-3), thereby attenuating endothelial injury and supporting cardiovascular protection in both diabetic and non-diabetic settings [171]

Of note, such effective compensation in rodent brain includes the apparent ability to avoid a rise in mitochondrial ROS in Sod2- haploinsufficient and bi-genic mice, possibly due to rapid shuttling of O 2 into the cytosol for processing by alternate SOD activities (Fig

Compared with traditional chemical drugs, natural compounds extracted from Chinese herbs have the advantages of fewer side effects and low long-term toxicity

Dopamine may still play a role in this scenario