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It is believed that early stages of frailty are amenable to interventions that could avert adverse outcomes, including the increased risk of hospitalization and premature death (116)

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Notably, the mitochondrial pyruvate carrier serves as the sole entry point for the entry of pyruvate into mitochondria

1 H-NMR(D 2 O, ppm): 2.22.4(m, 2H, CH 2 CO 2 HN(H)Pr i 2 ), 2.52.8(m, 2H), 3.13.2(m, 1H, 3-H) 13 C-NMR(D 2 O, ppm): 40.92(CH 2 CO 2 HN(H)Pr i 2 ), 48.12(4-CH 2 ), 51.02(3-CH), 178.95(CO 2 HN(H)Pr i 2 ) t-butyl amine (571 mg, 7.81 mmol) was added to the reacting solution of D 2 O containing (S)-4-hydroxy-3-methanesulfonyl hydroxybutyric acid, so prepared from Example 3 and stirred at room temperature for 4 hours