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In the clinical conditions presented in the review, increased intestinal permeability has been demonstrated, but the central question of whether the barrier dysfunction is a primary event in the pathophysiology or a consequence of the disease is still not resolved in most diseases

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If this happens consistently, switch to a shorter needle, use a 45-degree angle instead of 90 degrees, or choose a site with more subcutaneous tissue like the abdomen

The technology also limits certain errors by preventing the instrument from drifting beyond the planned boundaries