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Chromatin immunoprecipitation sequencing revealed 5 GATA binding sites in a regulatory region 31 kb upstream of NBEAL2 covered by a H3K4Me1 mark indicative of an enhancer locus

10.1016/j.prmcm.2022.100173 577

This inactivation manifested primarily as a reduction in the number of opioid binding sites via two steps: a rapid phase that destroyed up to 50% of opioid binding within 60 seconds, and a second slower phase