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Exogenous supplementation of Monounsaturated Fatty Acid(MUFA), stearoyl-CoA desaturase (SCD1)-mediated cellular MUFA production, and Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3)-dependent MUFA membrane enrichment have been reported to reduce the propensity of cells to die by ferroptosis (37).The main byproduct of lipid peroxidation is lipid hydroperoxides

Figure 13 summarizes key intracellular glutathione (GSH) sensing strategies, encompassing fluorescent probes that detect reduced GSH through light emission, enzymatic biosensors that generate electrical signals via GSHNAD(P)H redox cycling, quantum nanoprobes that enable high-resolution fluorescence shifts, and nanomaterial-based sensors that act as GSH-responsive reporters for gene editing and signal amplification

Future research should integrate traditional Chinese medical practices with modern medical studies to explore additional pathways between ferroptosis and UC

The intestinal immune system