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Furthermore, expression of SLC7A11, a GSTO1 and C1-27 target gene, was increased in C1-27 -treated tumours indicating target engagement (Fig

Notably, inhibition of ARG1 effectively relieves the metabolic constraint on T cells and promotes their robust expansion

doi:10.1016/j.ijbiomac.2018.09.058 98

However, the restoration of hepatic enzyme production over weeks could theoretically alter metabolism of drugs processed by the liver, potentially requiring dose adjustments for medications with narrow therapeutic windows