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Across several phase II/III programs of rosiglitazone XR, including adjunctive and monotherapy designs with APOE-4 stratification (e.g., NCT00428090, NCT00348309, and NCT00348140) and extended open-label safety cohorts (NCT00381238, NCT00490568, NCT00550420, and NCT00265148), no reproducible treatment advantage emerged on the ADAS-Cog, CDR-SB, or global clinical impressions relative to standard-of-care and placebo

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Ethical Approval This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors

In anemic cats and goats with these endogenous Heinz bodies or dogs with low to moderate numbers of eccentrocytes without Heinz bodies, the anemia is more likely that the underlying disease causing the oxidative injury is also causing the anemia (which is frequently due to bone marrow suppression or a hemolytic process from inflammatory or chronic disease)