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Although Grx are mainly responsible for deglutathionylation reactions, recent evidence has indicated a role for Grx in protein glutathionylation, mediated by the stabilization of a GSH thiyl radical which is then subsequently transferred to an available protein thiol (Starke et al., 2003)

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Despite significant advancements in our understanding of COPD, the complex molecular mechanisms underlying CS-induced lung damage remain incompletely understood