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Similarly, Dengue infection also leads to ROS accumulation, resulting from the degradation of Nrf2 by a viral protein (NS2B3), leading to increased viral replication and inflammatory or apoptotic gene expression 35

Mutations in B12 metabolic pathways may impair this conversion in a subset of individuals

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P62 can ubiquitinate damaged mitochondria and trigger mitophagy to avoid activating caspase-1 [207]