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Sci Total Environ, 103: 57-71

In this regard, it is interesting to note that a Bruton tyrosine kinase inhibitor that targets Fc-receptor signaling in macrophages is being tested in a randomized clinical trial 45

Intrigued by the advantages of PROTACs in degrading dysfunctional proteins, herein, we devised an in-situ formed TYR degrader by utilizing the potent catalytic performance of TYR (Fig