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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

Unfortunately, MRS signals are of little aid of differentiating synaptic glutamate from the intracellular glutamate-related compounds (266)

65 Although animal models of RA have been useful, they do not always reliably replicate the human disease phenotype, even less the ACPA-positive RA

The main risks include cardiovascular effects such as elevated heart rate, hypertension, and palpitations