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CagriSema (the combination) was submitted for FDA approval in December 2025, but cagrilintide on its own is earlier in the process

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The first available amylin agonist was pramlintide, which is already approved for treatment of type 1 and type 2 diabetes in conjunction with insulin [4]

Using Gdf11 cKO mice, we demonstrate for the first time that GDF11 is required for the normal proliferation of adult neural progenitor cells