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Specifically, when mitochondrial DNA leaks, it triggers the immune response, including interferon activation, as a danger signal from the damaged mitochondria.[ref] Some viral infections also trigger mitophagy, or mitochondrial destruction, which works to help the virus evade the immune response.[ref] Interleukin-2 is an inflammatory cytokine that plays an integral role in activating T cells, NK cells, and macrophages

10.1111/cen.13003 Clin Endocrinol (Oxf)

I think it can be helpful to everyone to know that even though it feels better at a mental level to get into the cold slowly, it is actually much worse from a neurobiological perspective