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McElvaney OJ, Curley GF, Rose-John S, McElvaney NG

Another experiment carried out using 96 h exposure to As (based on LD 50 values) in spottail shiner ( Notropis hudsonius ), chum salmon ( Oncorhynchus keta ), common minnow ( Phoxinus phoxinus ) and fathead minnow ( Pimephales promelas ) showed fins were more affected than edible muscle tissues (Lima et al

Martin and Delarasse, 2018)

These mutations lead to constitutive activation of Ras, resulting in persistent activation of the MAPK pathway, promoting uncontrolled cell proliferation and survival