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The biomarker clusters with increased lactate, pyruvate, alanine, and sometimes tricarboxylic acid cycle (TCA) intermediates (Figure 5, group 1), suggest dysfunction of oxidative phosphorylation or the TCA cycle

Scholte HR, Luyt-Houwen IEM, Vaandrager-Verduin MHM

Saiki and colleagues identified marker genes for the differential diagnosis of CFS i.e., the expression of GZMA , PSMA3 , PSMA4 , COX5B , ATP5J2 , and DB1 was decreased while the expression of STAT5A was upregulated in CFS individuals (Saiki et al