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Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 1720

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Shoot length showed a clear distinction between the two genotypes, with LY46 maintained robust growth under stress conditions, whereas HGN experienced a significant reduction in shoot length under stress (Fig