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Patients with hepatic impairment may have higher plasma hydrocodone concentrations than those with normal function

Prenatal and Postnatal Neuroinflammation and Neurodevelopment Neurodevelopment is a highly organized process, beginning with neurogenesis and migration of young neurons followed by synaptogenesis, synaptic pruning and myelination (Knuesel et al., 2014) (see Figure 1)

More studies using genetic models such as APP null mice or -secretase beta-site APP-cleaving enzyme 1 (BACE1) null mice display a range of dysfunctions such as lowered synaptic plasticity, restricted neurogenesis and cognitive deficits (Cai et al., 2023)