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Activation of NF-B pathway is responsible for macrophage 1 polarization [classically activated macrophage (M1)] which secrets inflammatory cytokines such as IL-1, IL-6, IL-12, Tumour necrosis factor alpha (TNF-), chemokines such as Monocyte chemoattractant protein-1 (MCP-1), IL-18, Regulated upon Activation, Normal T cell Expressed, and Secreted (RANTES), Macrophage inflammatory protein-2 (MIP-2), C-X-C Motif Chemokine Ligand 1 (CXCL1) and C-X-C motif chemokine ligand 10 (CXCL10) and adhesion molecules such as Intercellular Adhesion Molecule 1 (ICAM-1) and Vascular cell adhesion protein 1 (VCAM-1) (Liu et al., 2017)

Recent studies have also found that IVM could promote the death of tumor cells by regulating the tumor microenvironment in breast cancer

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I felt like Bradley Cooper in the movie Limitless after I started taking Betaine with Pepsin