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In our study we find a largely retained level of pupil response in the AD mice during startle responses, which under physiological circumstances would suggest that the noradrenergic system was working normally, as a strong correlation between locus coeruleus activity and pupil responses have been established (Reimer et al

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Systemic chemotherapeutic agents, particularly cyclophosphamide (CPX) and other nitrogen mustard alkylating agents, cause severe clinical manifestations such as cystitis (102)

Cancer Cell (2015) 27:45061