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NRF2-mediated regulation of ferroptosis NRF2, encoded by the NFE2L2 gene, is precisely regulated by the E3-ubiquitin ligase system [83,84,85]

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Calpain-I could fragment the recombinant TDP-43 A315T and M337V mutant proteins more rapidly than the wild-type TDP-43, whereas the D169G mutant TDP-43 was more efficiently cleaved by caspase-3 in vitro (Yamashita et al., 2012