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Bottom panel: 8-Isoprostane levels were reduced by 35% in the low dose group (gray bar) at week 2

Liu RT, Gao J, Cao S et al (2013) Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration

However, the CAT pathway exhibited a divergent regulatory pattern: despite the activation of other antioxidants, CAT activity remained suppressed

The activation of NOX and iNOS can cause the production of ROS and RNS, resulting in the depletion of GSH and GPX and aggravating lipid peroxidation [54]