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Increased stress susceptibility and impaired differentiation of astrocytes and neurons was found in co-cultures and in neural organoids generated from AxD patient-derived induced pluripotent stem cells with AxD-causing GFAP R239C mutation 334

The first helminthic therapy trial for MS was published in 2011 (110)

Patients with GFR above 60mls/min/1.73m2, without either persistent albuminuria or known structural or hereditary renal disease, do not have kidney disease and do not require investigation

These criteria were later updated to allow for two titanium plates and one burr hole cover (18.5 mm diameter) and to permit smaller separations, assessed by an MR safety expert and a neuroradiologist, with scans performed in normal operating mode (scanner-reported 6-min local 10 g SAR limit of 10 W/kg)