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A possible link between astrocyte activation and tau nitration in Alzheimers disease

This may relate to increased hydrostatic pressure that occurs during fetal development as systemic blood pressure rises in parallel with plasma protein concentration that provides the colloid osmotic pressure important for fluid exchange across capillaries

doi: 10.1002/smll.202006231 159 GaoXHuangHPanCMeiZYinSZhouLet al

Saggu S, Kumar R (2007) Possible mechanism of adaptogenic activity of sea buckthorn ( Hippophae rhamnoides ) during exposure to cold, hypoxia and restraint (CHR) stress induced hypothermia and post stress recovery in rats