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g , Violin plots showing relative fold change (log 2 ) in IP protein abundance associated with indicated organelles from HEK293T cells expressing ER-tag compared to those expressing control-tag

MitoTEMPO, a mitochondrial antioxidant, can directly target mitochondria through the targeted design of antioxidants and related carriers, and can be rapidly transformed into a ubiquinol form with strong antioxidant activity, effectively eliminating ROS and suppressing oxidative stress ( SS-31 is a mitochondria-targeted peptide that selectively localizes to the inner mitochondrial membrane and reduces mtROS accumulation in a dose-dependent manner (Zhao et al., 2004)

The expression of ced-3/ICE rapidly induces apoptosis, demonstrating that this gene encodes a cysteine protease essential for programmed cell death [127129]

Its levels also naturally decline with age