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This binding prevents misfolding and aggregation of procollagen and facilitates its transport to the Golgi apparatus ( Clinical and preclinical evidence supports a critical role for HSP47 in fibrogenesis

doi:10.1021/acs.chemrev.5b00484 42

It may cause wrinkles, age spots, and loss of firmness of the skin

Conclusion: Type VII collagen degradation may provide an early indication of metabolic stress associated with enhanced activity of matrix metalloproteinases causing tissue remodeling driving tissue changes during the early stages of NAFLD