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The CRF system is responsible for HPA-axis dysregulation followed by alterations in the extended amygdala, an extra-hypothalamic area composed of the central amygdala (CeA), BNST, and a transition zone in the posterior part of the medial NAc (Koob, 2008)

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Following phosphorylation by JAKs, STATs translocate to the nucleus to modulate gene transcription

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